尨挊榑暥

2023

丒Yuta Komori, Shun Sugimoto, Toranosuke Sato, Honoka Okawara, Ryo Watanabe, Yuki Takano, Satoshi Kitaoka, Yuya Egawa, A new boron-rhodamine-containing carboxylic acid as a sugar chemosensor, Sensors, 23(3): 1528 (2023). https://doi.org/10.3390/s23031528.

丒Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Fumiaki Sato, Eiji Tanaka, Hisashi Takeda, Tomoo Hosoe, Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds, J. Nat. Med. (2023). https://doi.org/10.1007/s11418-022-01673-8

2022

丒Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe, Secalonic acid and benzoic acid analogues exhibiting cytotoxicity against cancer cells isolated from Claviceps yanagawaensis, Adv. Microbiol., 12: 649-670 (2022).

2021

丒Hinako Kikuchi, Yuki Nakamura, Chika Inoue, Sayaka Nojiri, Miho Koita, Minori Kojima, Hiroki Koyama, Ryotaro Miki, Toshinobu Seki, and Yuya Egawa, Hydrogen peroxide-triggered conversion of boronic acid-appended insulin into insulin and its application as a glucose-responsive insulin formulation, Mol. Pharm., 18: 4224-4230 (2021).

丒Ryotaro Miki, Tomoya Yamauchi, Kosuke Kawashima, Yuya Egawa, Toshinobu Seki, Multinuclear NMR study on the formation and polyol-induced deformation mechanisms of worm-like micelles composed of cetyltrimethylammonium bromide and 3-fluorophenylboronic acid, Langmuir, 37: 3438-3445 (2021).

2020

丒Yuki Kobayashi, Yu Kojima, Ryotaro Miki, Toshinobu Seki, Yuya Egawa, Rotaxa-polymeric-gelation of acrylamides with vinyl-兝-cyclodextrin, J. Incl. Phenom. Macrocycl. Chem., 98: 43-48 (2020).

丒Jun Kurihara, Masaki Uchida, Tsutomu Yamaki, Tomomi Hatanaka, Toshinobu Seki, Hideshi Natsume, Effect of Hydrophilic Chain Length in Non-Ionic Surfactant on the Physicochemical Characteristics, Gene Expression Efficiency and Cytotoxicity of DNA/Poly-L-Ornithine/Niosome Ternary Complexes for Gene Delivery, J. Pharm. Sci. Technol., Jpn., 80, 156-161 (2020).

2019

丒Yui Ohno, Tomohiro Seki, Yu Kojima, Ryotaro Miki, Yuya Egawa, Osamu Hosoya, Keizo Kasono, Toshinobu Seki, Investigation of factors that cause insulin precipitation and/or amyloid formation in insulin formulations, J. Pharm. Health Care Sci., 5: 22 (2019).

丒Yui Ohno, Momoko Kawakami, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Yuya Egawa,
Cell adhesive character of phenylboronic acid-modified insulin and its potential as long-acting insulin,
Pharmaceuticals, 12: 121 (2019).

2018

丒Yuki Kobayashi, Yu Kojima, Ryotaro Miki, Toshinobu Seki, Takashi Fujihara, Yoshihiro Ishimaru, and Yuya Egawa,
Single-step preparation of topological gels using vinyl-modified 兝-cyclodextrin as a figure-of-six cross-linker,
J. Incl. Phenom. Macrocycl. Chem., 92: 311-317 (2018).

丒Chihiro Takei, Yui Ohno, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Yuya Egawa,
Sugar-Responsive Layer-by-Layer Film Composed of Phenylboronic Acid-Appended Insulin and Poly(vinyl alcohol),
Chem. Pharm. Bull., 66: 368-374 (2018).

丒Ryotaro Miki, Chihiro Takei, Yasushi Ohtani, Kosuke Kawashima, Ayaka Yoshida, Yu Kojima, Yuya Egawa, Toshinobu Seki, Daisuke Iohara, Makoto Anraku, Fumitoshi Hirayama, and Kaneto Uekama,
Glucose Responsive Rheological Change and Drug Release from a Novel Worm-like Micelle Gel Formed in Cetyltrimethylammonium Bromide/Phenylboronic Acid/Water System,
Mol. Pharm., 15:1097-1104 (2018).

2017

丒Ryotaro Miki, Yuuichi Hara, Nahomi Imai, Masahiro Sugino, Yuya Egawa, Osamu Hosoya, Kazuhiko Juni, Toshinobu Seki,
A study on an in vitro changeable pH dissolution/permeation system that reflects pH shifts of the gastrointestinal tract: a case of a poorly soluble basic drug,
AATEX, 22:107-114 (2017).

丒Wataru Uchida, Maiki Yoshikawa, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Takashi Fujihara, Yoshihiro Ishimaru, Yuya Egawa,
A polyrotaxane gel using boronic acid-appended 兞-cyclodextrin as a hybrid cross-linker,
J. Incl. Phenom. Macrocycl. Chem., 89: 281-288 (2017).

丒Yutaro Hazama, Wataru Uchida, Toshihisa Maekawa, Ryotaro Miki, Shinji Oshima, Yuya Egawa, Osamu Hosoya, Toshinobu Seki,
Preclinical Study of Tacrolimus Ointment for Prevention of Its Systemic Absorption in Atopic Dermatitis Model Mice According to Their Skin Conditions,
Jpn. J. Pharm. Health Care Sci., 43: 477-491 (2017).

丒Yu Kojima, Tomoyuki Okano, Tomohiro Seki, Misato Namiki, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki,
Polyol-responsive pseudopolyrotaxanes based on phenylboronic acid-modified polyethylene glycol and cyclodextrins,
J. Incl. Phenom. Macrocycl. Chem., 87:295-303 (2017).

2016

丒Ryotaro Miki, Yuki Kobayashi, Yuko Nakamura, Tomoko Asaka, Nahomi Imai, Yuka Hirayama, Osamu Hosoya, Yuya Egawa, Toshinobu Seki,
The development of a novel in vitro gastrointestinal absorption model comprising drug dissolution/migration/permeation processes: interactions between a drug and an excipient,
AATEX, 21:1-13 (2016).

丒Tomohiro Seki, Keigo Abe, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki,
A pseudopolyrotaxane for glucose-responsive insulin release: The effect of binding ability and spatial arrangement of phenylboronic acid group,
Mol. Pharmaceutics, 13:3807-3815 (2016).

丒Naoki Shimomura, Yuya Egawa, Ryotaro Miki, Takashi Fujihara, Yoshihiro Ishimaru, Toshinobu Seki,
Red fluorophore comprising of a borinate-containing xanthene analogue as a polyol sensor,
Org. Biomol. Chem., 14:10031-10036 (2016).

丒Yutaro Hazama, Toshihisa Maekawa, Ryotaro Miki, Shinji Osima, Yuya Egawa, Kazuhiro Morimoto, Toshinobu Seki, Effect of physiological changes in the skin on systemic absorption of tacrolimus following topical application in rats,
Biol. Pharm. Bull., 39:343-352 (2016).

2015

丒Keisuke Suwa, Munenari Nagasaka, Satoshi Niina, Yuya Egawa, Toshinobu Seki, Jun-ichi Anzai,Sugar-response of layer-by-layer films composed of poly(vinyl alcohol) and poly(amidoamine) dendrimer bearing 4-carboxyphenylboronic acid,
Colloid and Polymer Science, 293:1043-1048 (2015).

丒Tomohiro Seki, Keigo Abe, Kiminobu Nakamura, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni,Toshinobu Seki,Sugar-responsive pseudopolyrotaxanes and their application in sugar-induced release of PEGylated insulin,
J. Incl. Phenom. Macrocycl. Chem., 82:417-424 (2015).

丒Tomohiro Seki, Misato Namiki, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki, Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and
兞-Cyclodextrin,
Materials, 8: 1341-1349 (2015)

丒Ryotaro Miki, Yasuna Ichitsuka, Takumi Yamada, Soichiro Kimura, Yuya Egawa, Toshinobu Seki, Kazuhiko Juni, Hideo Ueda, Yasunori Morimoto,
Development of a membrane impregnated with a poly(dimethylsiloxane)/poly(ethylene glycol) copolymer for a high-throughput screening of the permeability of drugs, cosmetics, and other chemicals across the human skin,
Eur. J. Pharm. Sci., 66: 41-49 (2015)

2014

丒Katsunori Shinohara, Miki Yamashita, Wataru Uchida, Shinji Oshima, Yuya Egawa, Ryotaro Miki, Osamu Hosoya, Tohru Kishino, Toshinobu Seki, Kazuhiko Juni,
Preparation of polypseudorotaxanes composed of cyclodextrin and polymers in microspheres,
Chem. Pharm. Bull., 62: 962-966 (2014)

丒Yamaki T, Kamiya Y, Ohtake K, Uchida M, Seki T, Ueda H, Kobayashi J, Morimoto Y, Natsume H,
A Mechanism Enhancing Macromolecule Transport Through Paracellular Spaces Induced by Poly-L-Arginine: Poly-L-Arginine Induces the Internalization of Tight Junction Proteins via Clathrin-Mediated Endocytosis,
Pharm Res, 31: 2287-2296 (2014)

丒Ryota Watahiki, Katsuhiko Sato, Keisuke Suwa, Satoshi Niina, Yuya Egawa, Toshinobu Seki, Jun-ichi Anzai,
Multilayer films composed of phenylboronic acidmodified dendrimers sensitive to glucose under physiological conditions,
J. Mater. Chem. B, 2: 5809-5817 (2014)

2013

丒Kiminobu Nakamura, Tomohiro Seki, Yuya Egawa, Ryotaro Miki, Yoshiki Oda, Takashi Yamanoi and Toshinobu Seki,
Sugar-Sensitive Supramolecular Structures Based on Phenylboronic Acid-Modified Cyclodextrins,
Chem. Pharm. Bull., 61: 1188-1191 (2013)

丒Toshinobu Seki, Airi Hamada, Yuya Egawa, Tsutomu Yamaki, Masaki Uchida, Hideshi Natsume, Soichiro Kimura and Hideo Ueda,
Evaluation of the Effects of Absorption Enhancers on Caco-2 Cell Monorayers by Using a Pore Permeation Model Involving Two Defferent Sizes,
Biol. Pharm. Bull., 36: 1862-1866 (2013)

2012

丒Takahiro Rikita, Yuya Egawa, Toshinobu Seki,
Fluorometric determination of inulin using 5-quinolineboronic acid and inulinase,
Anal. Biochem., 426: 24-26 (2012)

丒Shinji Oshima, Chihiro Suzuki, Rina Yajima, Yuya Egawa, Osamu Hosoya, Kazuhiko Juni, Toshinobu Seki,
The use of an artificial skin model to study transdermal absorption of drugs in inflamed skin,
Biol. Pharm. Bull., 35: 203-209 (2012)

2011

丒Toshinobu Seki, Nanako Fukushi, Hiroto Maru, Soichiro Kimura, Sumio Chono, Yuya Egawa, Kazuhiro Morimoto, Hideo Ueda, Yasunori, Morimoto,
Effects of sperminated pullulans on the pulmonary absorption of insulin,
Yakugaku Zasshi, 131: 307-314 (2011)

丒Soichiro Kimura, Kaori Miyazaki, Ryotaro Miki, Takeshi Shimamura, Sachihiko Numajiri, Toshinobu Seki, Kazuhiko Juni, Hiromi Kitano, Hideo Ueda, Yasunori Morimoto,
Evaluation of an artificial polymer membrane as a human skin alternative membrane available for formulation tests of transdermal products,
J. Pharm. Sci. Technol. Jpn., 71(3), 191- 196 (2011)

丒Masaki Uchida, Hideshi Natsume, Toshinobu Seki, Tateki Uchida, Yasunori Morimoto,
Relationship between the particle velocity and introduction of drug-loaded microparticles into the skin in a microparticulate bombardment system,
Chem. Pharm. Bull., 59(5), 662-665 (2011)

2010

丒Toshinobu Seki, Takaaki Kiuchi, Hiroki Seto, Soichiro Kimura, Yuya Egawa, Hideo Ueda, Yasunori Morimoto,
Analysis of the rat skin permeation of hydrophilic compounds using the Renkin function,
Biol. Pharm. Bull., 33: 1915-1918 (2010)

丒Shinji Oshima, Tatsuya Sashida, Yuya Egawa, Osamu Hosoya, Kazuhiko Juni, Toshinobu Seki,
Study of a drug interaction involving the permeation process using an artificial skin model as an alternative to animal skin,
AATEX, 15: 97-105 (2010)

丒Yuya Egawa, Yoshiyuki Tanaka, Ryota Gotoh, Satoshi Niina, Yu Kojima, Naoki Shimomura, Hiroko Nakagawa, Toshinobu Seki, Jun-ichi Anzai,
Nitrogen-15 NMR spectroscopy of sugar sensor with B-N interaction as a key regulator of colorimetric signals,
Chem. Lett., 39: 1188-1189 (2010)

丒Ryotaro Miki, Soichiro Kimura, Hideo Ueda, Takeshi Shimamura, Sachihiko Numajiri, Toshinobu Seki, Kazuhiko Juni, Hiromi Kitano, Yasunori Morimoto,
Suitability of synthetic copolymer membranes as a human skin alternative for in vitro skin permeation testing,
AATEX, 15: 14-27 (2010)

丒Kohei Togami, Sumio Chono, Toshinobu Seki, Kazuhiro Morimoto,
Aerosol-based efficient delivery of telithromycin, a ketolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections,
Drug Dev. Ind. Pharm., 36: 861-866 (2010)

丒Kohei Togami, Sumio Chono, Toshinobu Seki, Kazuhiro Morimoto,
Intracellular pharmacokinetics of telithromycin, a ketolide antibiotic, in alveolar macrophages,
J. Pharm. Pharmacol., 62, 71-75 (2010)

2009

丒Kohei Togami, Sumio Chono, Toshinobu Seki, Kazuhiro Morimoto,
Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages,
Drug Metab. Pharmacokinet., 24, 411-417 (2009)

丒Toshinobu Seki, Osamu Hosaya, Hideshi Natsume, Izumi Sato, Yuya Egawa, Hiroko Nakagawa, Kazuhiko Juni, Yasunori Morimoto,
Application of the Renkin function to characterize paracellular pathways in the nasal absorption of FITC-dextrans in rats,
J. Drug Del. Sci. Tech., 19, 331-335 (2009)

丒Sumio Chono, Rie Fukuchi, Toshinobu Seki, Kazuhiro Morimoto,
Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery,
J. Control. Release, 137, 104-109 (2009)

丒戝栰丂桾徍丄壀嶈岝梞丄嶗堜丂岝堦丄娭丂弐挩丄懞忋丂旤曚丄憗惃丂怢惓丄搰怷丂旤岝丄孲丂廋摽丄嵅摗丂廳堦丄搉曈丂堦峅丄搉曈丂懽桾丄憗悾丂岾弐丄巗尨丂榓晇丄
夘岇丒梴岇巤愝偵偍偗傞俀擭師妛惗傪懳徾偲偟偨懱尡宆妛廗偺幚巤偲昡壙乗抧堟堛椕傊峷專偡傞堛椕恖偺梴惉傪栚巜偟偰乗丄
幮夛栻妛丄27, 27-31 (2009)

丒Hideo Ueda, Mizue Mutoh, Toshinobu Seki, Daisuke Kobayashi, Yasunori Morimoto,
Acoustic cavitation as an enhancing mechanism of low-frequency sonophoresis for transdermal drug delivery,
Biol. Pharm. Bull., 32, 916-920 (2009)

2008

丒Yuya Egawa, Ryota Gotoh, Toshinobu Seki and Jun-ichi Anzai,
Sugar response of boronic acid-substituted azobenzene dye-modified polymer,
Mater. Sci. Eng. C, 29, 115-118 (2009)

丒Toshinobu Seki, Nanako Fukushi, Sumio Chono, Kazuhiro Morimoto,
Effects of sperminated polymers on the pulmonary absorption of insulin,
J. Control. Release, 125, 246-251 (2008)

丒Kazuhiro Morimoto, Sumio Chono, Tadashi Kosai, Toshinobu Seki,
Design of cationic microspheres based on aminated gelatin for controlled release of peptide and protein drugs,
Drug Delivery, 15, 113-117 (2008)

丒Kazuhiro Morimoto, Nanako Fukushi, Sumio Chono, Toshinobu Seki,
Yasuhiko Tabata, Sperminated dextran, a cationized poltmer, as absorption enhancer for pulmonary application of peptide drugs,
Pharmazie, 63, 180-184 (2008)

丒Sumio Chono, Tomoharu Tanino, Toshinobu Seki, Kazuhiro Morimoto,
Efficient drug targeting to rat alveolar macrophages by pulmonary administration of ciprofloxacin incorporated into mannosylated liposomes for treatment of respiratory intracellular parasitic infections,
J. Control. Release, 127, 50-58 (2008)

丒Sumio Chono, Tomoharu Tanino, Toshinobu Seki, Kazuhiro Morimoto,
Efficient drug delivery to alveolar macrophages and lung epithelial lining fluid following pulmonary administration of liposomal ciprofloxacin in rats with pneumonia and estimation of its antibacterial effects,
Drug Dev. Ind. Pharm., 34, 1090-1096 (2008)

丒Yuya Egawa, Ryosuke Hayashida, Toshinobu Seki and Jun-ichi Anzai,
Fluorometric determination of heparin based on self-quenching of fluorescein-labeled protamine,
Talanta, 76, 736-741 (2008)

憤愢

2019

丒Yuya Egawa, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki,
Sugar-responsive smart materials based on phenylboronic acid and cyclodextrin,
J. Incl. Phenom. Macrocycl. Chem., 94: 1-10 (2019)

丒嶰栘 椓懢榊,
僼僃僯儖儃儘儞巁傪梡偄偨僌儖僐乕僗墳摎惈怴婯昍忬儈僙儖僎儖偺挷惢偲栻暔曻弌摿惈,
僆儗僆僒僀僄儞僗丄19, 5-11 (2019)

2017

丒峕愳 桽嵠,
摐墳摎惈暘巕儅僔儞偵傛傞僀儞僗儕儞僐儞僩儘乕儖僪儕儕乕僗,
栻嵻妛丄77, 242-247 (2017)

2014

丒Yuya Egawa, Ryotaro Miki, Toshinobu Seki,
Colorimetric Sugar Sensing Using Boronic Acid-Substituted Azobenzenes,
Materials, 7: 1201-1220 (2014)

2013

丒峕愳丂桽嵠,丂娭丂弐挩丄
摐墳摎惈僀儞僗儕儞儕儕乕僗僔僗僥儉傪巜岦偟偨挻暘巕僫僲儅僔儞丄
栻妛嶨帍丄133, 1287-1295丂(2013)

丒娭丂弐挩丄
乬僔儕乕僘丂尋媶幰偵暦偔宱旂媧廂丂恖岺崅暘巕枌傪梡偄偨宱旂媧廂偺幚尡偵偮偄偰乭丄
COSME TECH JAPAN丄 10, 41-46 (2013)

2012

丒娭丂弐挩丄
僀儞僗儕儞偺宱旲僨儕僶儕乕偵娭偡傞婎慴揑尋媶丄
栻妛嶨帍丄132, 1255-1262 (2012)

2011

丒Yuya Egawa, Toshinobu Seki, Shigehiro Takahashi, Jun-ichi Anzai,
Electrochemical and optical sugar sensors based on phenylboronic acid and its derivatives,
Mater. Sci. Eng. C, 31, 1257-1264 (2011)

2010

丒娭丂弐挩丄
僇僠僆儞惈崅暘巕傪梡偄偨僀儞僗儕儞偺擲枌媧廂懀恑丄
栻妛嶨帍丄130丗 1115-1121 (2010)

丒娭丂弐挩丄
堛椕偺僯乕僘傪傆傑偊偨宱旂媧廂嵻乮慡恎惈乯偺張曽愝寁丄
PHARM STAGE丄10: 25-28 (2010)

挊彂